Identification of clinical and demographic variables associated with severe Covid-19 in subjects with rheumatic disease in a third-level hospital in Mexico City

Dear editor: Subjects with rheumatic diseases are a group with risk for clinical complications by Covid-19.1 Some demographic and clinical variables have been identified as risk factors for severe Covid-19 in infected people, but is not clear whether these predictors might further increase risk in patients with rheumatic diseases.2 In this retrospective study based on a systematic sampling from May 2020 to July 2021, we assessed severity-associated risk generated by Covid-19 between a group of patients with rheumatic diseases (54.5%, n=36, RDs group) and another group without immunological deterioration (45.4%, n=30, NRs patients) (Protocol Register Number 09-CEI-005-20201111). Clinical and demographic data from sixty-six patients with Covid-19 confirmed by PCR testing and computed tomography for lung lesions were collected (table I). Severity in patients were classified based on oxygen requirement levels since non-severe condition (PaO2 /FiO2 >95%) or any other condition according with the World Health Organization criteria.3 Results showed that 11.1% of RDs patients required mechanical ventilation, 47.2% required any oxygen supplement and 41.7% were classified as non-severe Covid-19 while all non-rheumatic cohort required any minor oxygen support. Analysis by logistic regression models identified that the risk for clinical complications such as acute respiratory distress syndrome (ARDS) were associated with the presence of diabetes mellitus type-2 (DMT-2) (OR: 5.61 [1.7747,17.7367], p-value<0.05). Particularly, in RDs group the risk for severe Covid-19 were associated with the presence of DMT-2 (OR: 21.00 [1.7343,254.274], p<0.05), which was nine times higher than in NRs group. Our data are similar with reports in where presence of comorbidities are associated with hospitalization due to severe Covid-19.4 Moreover, clinical parameters were associated to severe Covid-19 in RDs group including creatinine >1.5 mg/ dL (OR: 1.6875 [0.3043,9.3584], p<0.05);alanine aminotransferase enzyme ≥40 U/L (OR: 9.000 [1.1257,71.9578], p<0.05), lymphocytes counts <1000 per mL (OR: 13.50 [1.3793,1315789], p<0.05) and hemoglobin <10 g/dL (OR: 18.75 [1.5434,227.7808], p<0.05). These increases in risk could be explained by immunological disfunction own of each rheumatic disease or by genetic variants of the adaptive and innate immune system.5 In this study, we concluded that individuals with rheumatic disease have an increased risk for very severe Covid-19 and non-rheumatic predictors may affect them even more than general population. © 2023,Salud Publica de Mexico. All rights reserved.

Effect produced by physical activity and inactivity during covid-19 according to physical education pedagogy students

During the last years, physical activity and physical education classes in all age groups have been affected by the Sars-Cov-2 pandemic. The objective of this research was to reveal the perceptions about the effect that physical activity produces during COVID-19 according to the discourse of students of the Physical Education Pedagogy career of the Autonomous University of Chile, Temuco campus. The method was qualitative with a case study design, where the participants were 21 Physical Education Pedagogy students. The information collection instrument was the semi-structured interview and the grounded theory was used for its analysis. It is concluded that COVID 19 increased a very high level of physical inactivity in people, which translates into a decrease in energy expenditure, a high level of stress, anxiety, which were caused by the isolation that occurred at some point. © Copyright: Federación Española de Asociaciones de Docentes de Educación Física (FEADEF).

Comparative study between delivery modalities in higher education during emergency remote teaching due to COVID-19

Despite the difficulties faced during Emergency Remote Teaching (ERT) because of the COVID-19 pandemic, it is also true that such a situation has left a series of learnings that educational institutions around the world should capitalize on. Under this scenario, interest arose in studying three delivery modalities (face-to-face, hybrid, and remote) at the university level, aiming to compare the students' learning level and their perceptions of each delivery modality. The present study was developed in a private university in Mexico, following a quantitative methodological approach involving 360 students and 14 professors from various schools and geographical locations. Data were collected through pre- and post-tests and a perception questionnaire for students. Findings suggest that the students' learning level in every modality varies by school and that students positively perceive the three delivery modalities, albeit identifying factors that foster and hinder their learning process in each one. The results of this study contribute to strengthening the research field on teaching during ERT, allowing educational institutions to make better decisions regarding the quality of the educational offer.

Digital Qualitative and Mixed Methods Research in the Transformation of Higher Education

The Covid-19 pandemic evidenced the need to carry out educational research with a vision of transformation. At the Autonomous Metropolitan University (UAM), a public higher education institution in Mexico, a group of professors used digital technologies to research and systematize their educational practice and that of their students and colleagues. This was relevant to identify effective educational practices and areas for improvement that could inform about the premises that must be considered to promote meaningful educational innovations within their local context. The concepts that guided this process were: change in educational practices [1] and systematization of experiences [2]. Thus, the objective of this text is to systematize the qualitative and mixed methods research processes carried out during the Covid-19 pandemic and how they informed the transformation of educational practices at UAM Cuajimalpa. Among the main results are the following: (a) The practice of qualitative and mixed research in digital environments allowed a deeper understanding of the teaching-learning process during the Covid-19 pandemic, (b) The systematization of experiences derived in the organization and reflection of professors' innovations, and (c) From the work of qualitative research and mixed methods, educational actors have become aware of the imperative for pedagogical change. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Adaptation of midline and mini-midline catheters for patients with COVID-19

Objective: to analyse the time of permanence andmain causes for removal of midline (20 cm) and mini-midline (10 cm) catheters in hospitalized patients, and to study the differences in patients with COVID-19. Method: a descriptive, cross-sectional, retrospective study conducted with data from clinical records in the Hospital Universitario Vall d´Hebron (Barcelona, Spain). The study includedcatheters insertedby the Infusion andVascular Access Nursing (IVAN) Team in patients hospitalized during 2020. Results: the study included 357 catheters in 305 patients (28.9% with COVID-19). The latter presented a higher rate of obesity (21.6% vs. 9.2%;p= 0.003). The median duration of catheters inserted was 11-12 days, without any difference by type of catheter or having COVID-19 (p= 0.88). The main cause for removal in both groups was the end of the treatment, and it was higher in patients without COVID-19 (65.7% vs. 53.1%;p= 0.031), followedby exitus in patients withCOVID-19 (22.9% vs. 8.9%;p= 0.001), and catheter occlusion in the rest (17.3% vs. 8.33%;p= 0.035). There were n= 4 cases of catheter infection and n= 31 suspected cases, without difference by diagnosis or type of catheter. There was no variation in the cause for removal according to the venous access selected. Conclusions: there are no differences in terms of duration of catheters according to their length, vein of insertion or COVID-19 diagnosis. Ultrasound-guided venipuncture, sterile technique and selection of type of catheter by a member of the IVAN team seem to reduce the complications associated. © 2022 DAE Editorial, Grupo Paradigma. All rights reserved.

Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital.

Background: COVID-19 may be a new risk factor for stroke. Stroke in COVID-19 varies from 1.1 to 8.1%. Various pathophysiological pathways predispose SARS-CoV-2 infected patients to stroke. Aim: To describe COVID-19 patients with acute stroke in one Colombian Center. Methods: From March 6 2020 and March 6 2021 records of patients with acute stroke and in-hospital positive PCR (Polymerase Chain Reaction) test for Sars-CoV-2 infection were reviewed. Demographic, stroke and COVID-19 characteristics were extracted. Continuous variables were reported in means and ranges. Categorical variables were presented in frequencies and percentage. A descriptive narrative was performed. Results: Of 328 acute stroke patients 14 (4.2%) tested positive for PCR SARS-CoV-2. Mean age 56.4 years with 57% males. Five were (35.7%) without vascular risk factors but 9 (64.3%) overweight. Brain infarct diagnosed in 11 (78.5%), 53% with anterior circulation syndromes. Mean NIHSS score 11.8 and 7 (63%) received intravenous thrombolysis. Acute inflammatory blood biomarkers (D-dimer, ferritin, LDH elevated) were positive in all. 11 (78.5%) had symptomatic COVID-19 before stroke with a mean latency of 7 days. 12 (85.7%) had severe COVID-19 and 6 (42.8%) required mechanical ventilation. Outcome was unfavorable in 9 (64.3%) (The Modified Rankin Scale (mRS) > 2), mean hospital stay was 21.8 days and in-hospital case fatality rate was 14.2%. Conclusion: In susceptible individuals COVID-19 predisposes to stroke. Hypercoagulation and immune thrombosis may be at the culprit for this state. In Colombia, COVID-19 patients with stroke have similar characteristics to the described worldwide.

A Mixed Frequency BVAR for the Euro Area Labour Market*

We introduce a Bayesian mixed frequency VAR model for the aggregate euro area labour market that features a structural identification via sign restrictions. The purpose of this paper is twofold: we aim at (i) providing reliable and timely forecasts of key labour market variables and (ii) enhancing the economic interpretation of the main movements in the labour market. We find satisfactory results in terms of nowcasting and forecasting, especially for employment growth. Furthermore, we look into the shocks that drove the labour market and macroeconomic dynamics from 2002 to 2022, with an insight also on the COVID-19 recession. While demand shocks were the main drivers during the Global Financial Crisis, technology and wage bargaining factors, reflecting the degree of lockdown-related restrictions and job retention schemes, have been important drivers of key labour market variables during the pandemic. © 2023 Oxford University and John Wiley & Sons Ltd.

From the exception to the rule: Exceptionality as a way of governing Colombia, 1961–2022

In Colombia, the state of exception is a legal and political mechanism in which the head of the executive branch extends its powers temporarily under the pretext of averting a serious confrontation to the constitutional order. However, despite its exceptional nature, the reality is that within the national legal and political culture, the use of this figure is rather normal. Thus, this article aims to assess the way in which exceptionality has become recurrent, through states of exception and other figures that allow a margin of maneuver to the extraordinary executive power and outside the radar of constitutional controls. Likewise, the text examines how the governments have taken advantage of the notion of exceptionality as a form of government, subtly prolonging the periods of exception to circumvent the constitutional controls imposed on them. To this end, the article focuses in particular on what has recently happened with the health emergency caused by COVID-19 in the country. For this purpose, historical, contextual and comparative analysis tools were used. © 2023, Onati International Institute for the Sociology of Law. All rights reserved.

A proposal for adapting the teaching methodology to the online context in the subject Structural Geomorphology

The exceptional situation experienced as a result of the health crisis produced by the Covid-19 pandemic has raised the need to adapt university teaching to a non-face-to-face context. Given this circumstance, virtual resources acquire high importance in reorganizing subjects in which field trips and fieldwork constitute an essential part of the teaching-learning processes. In the current health context, the difficulty of con-ducting field trips in safe conditions leads to an exploration of the usefulness of virtual resources that can mitigate or compensate for the lack of direct contact with the environ-ment. Academic geography must incorporate tools that allow students to visualize and understand the configuration of the natural environment, as a fundamental component for the knowledge of a territory and the interpretation of landscapes, where the structure of the relief acquires special relevance. © 2022, Universitat Autonoma de Barcelona. All rights reserved.

"Emotional drinking" during quarantine by COVID-19 in Chile: the role of depressive symptoms on problematic alcohol consumption

Aim: To assess the pattern of alcohol consumption in the Chilean adult population in association with depressive symptoms in the context of the COVID-19 quarantine. Method(s): A correlational and transversal study was conducted. Alcohol consumption and depressive symptoms were measured through an online survey, including the PHQ-9 Chilean version and the item banks for alcohol use of the Patient-Reported Outcomes Measurement Information System (PROMIS). Mediational analysis models were conducted to assess whether the relationship between depressive symptoms and problematic drinking was mediated by drinking to cope with negative emotions. Result(s): 32% of the sample reported depression, 84% acknowledge having been drunk during the previous 30 days and 18% acknowledge an increase in the amount of alcohol use. The presence of depressive symptomatology positively predicts problematic alcohol consumption during the quarantine;however, when it includes analyzing the reasons for drinking alcohol, this relationship becomes negative and shows a significant mediation effect in the relationship between depressive symptomatology and problematic drinking through increased drinking to control negative emotions. Conclusion(s): The findings suggest that during quarantine, the increase in problematic drinking is related to depressive symptoms associated with an increased urge to drink to cope with negative emotions.Copyright © 2022 Taylor & Francis Group, LLC.

Background rates of 41 adverse events of special interest for COVID-19 vaccines in 10 European healthcare databases - an ACCESS cohort study.

BACKGROUND: In May 2020, the ACCESS (The vACCine covid-19 monitoring readinESS) project was launched to prepare real-world monitoring of COVID-19 vaccines. Within this project, this study aimed to generate background incidence rates of 41 adverse events of special interest (AESI) to contextualize potential safety signals detected following administration of COVID-19 vaccines. METHODS: A dynamic cohort study was conducted using a distributed data network of 10 healthcare databases from 7 European countries (Italy, Spain, Denmark, The Netherlands, Germany, France and United Kingdom) over the period 2017 to 2020. A common protocol (EUPAS37273), common data model, and common analytics programs were applied for syntactic, semantic and analytical harmonization. Incidence rates (IR) for each AESI and each database were calculated by age and sex by dividing the number of incident cases by the total person-time at risk. Age-standardized rates were pooled using random effect models according to the provenance of the events. FINDINGS: A total number of 63,456,074 individuals were included in the study, contributing to 211.7 million person-years. A clear age pattern was observed for most AESIs, rates also varied by provenance of disease diagnosis (primary care, specialist care). Thrombosis with thrombocytopenia rates were extremely low ranging from 0.06 to 4.53/100,000 person-years for cerebral venous sinus thrombosis (CVST) with thrombocytopenia (TP) and mixed venous and arterial thrombosis with TP, respectively. INTERPRETATION: Given the nature of the AESIs and the setting (general practitioners or hospital-based databases or both), background rates from databases that show the highest level of completeness (primary care and specialist care) should be preferred, others can be used for sensitivity. The study was designed to ensure representativeness to the European population and generalizability of the background incidence rates. FUNDING: The project has received support from the European Medicines Agency under the Framework service contract nr EMA/2018/28/PE.

GRAPHICAL TOOLS TO THE RESCUE. HIGH RESOLUTION AERIAL PHOTOGRAPHY FOR THE LOCATION OF MISSING PERSONS

Since the COVID-19 pandemic changed the rules of the game in many work environments, adaptation has been a key factor. Restrictions such as social distance or confinement made searches for missing persons more difficult. Although mobility limitations led to a decrease in the number of disappearances, they did not stop completely and search teams had to adapt to the new scenario that prevented, for example, the participation of volunteers. For these reasons, it was decided to implement a tool that had been in development for years, based on the Collaboration Agreement signed in 2015 between the Servicio de Prevención y Extinción de Incendios de la Diputación Provincial de Zaragoza (SPEI-DPZ) and the University of Zaragoza. The tool is called Virtual Cloud Search and Rescue (VC-SAR) and is still under development by the authors of this communication. The following is a basic description of the tool and how it was applied in a real case, in which a missing person was being searched for. The device used made it possible to obtain about 5000 images of 44.7 mega-pixels, covering an area of over 2000 hectares. Thanks to the searches carried out, more than 100 pieces of evidence were found over the course of four days, which could be collected for on-site investigation by the Navarra Fire Service. All this was possible thanks to the collaboration of 5 different fire departments, belonging to three provinces, making possible the participation of a total of 53 searchers from different locations. © 2023 Authors. All rights reserved.

Challenges to Sustainability of Pediatric Early Warning System (Pews) in Resource-Limited Hospitals in Latin America

BACKGROUND AND AIM: Pediatric Early Warning Systems (PEWS) are evidence-based interventions that improve early identification of deterioration in resource-limited hospitals. While PEWS can be successfully implemented in these settings, little is known about their sustainability postimplementation. This study evaluates staff perspectives on the importance of, and challenges to, sustaining PEWS. METHOD(S): We conducted semi-structured interviews of PEWS implementation leaders and hospital directors at 5 pediatric oncology centers sustaining PEWS in Latin America. Interviews were conducted in Spanish, transcribed, and translated into English. A code book was developed combining a priori and inductively derived codes. Transcripts were independently coded by 2 coders achieving a kappa of 0.8-0.9. Thematic content analyses explored staff perceptions on PEWS sustainability. RESULT(S): We interviewed 71 staff including physicians (45%), nurses (45%), and administrators (10%). Participants emphasized the importance of sustaining PEWS for continued patient benefit. However, participants reported a range of challenges sustaining PEWS, including fluctuations in human and material resources needed for PEWS, staff turnover and insufficient training, difficulty achieving new leadership buy-in, lack of internal systems to promote ongoing monitoring of PEWS, and the COVID-19 pandemic (Table 1). Together, these challenges resulted in multiple impacts, ranging from a small reduction in PEWS quality to complete disruption of PEWS use resulting in loss of benefits to patient outcomes in some units. CONCLUSION(S): While sustainability of evidence-based interventions like PEWS is valued by staff in resourcelimited hospitals, participants reported multiple challenges to sustainability resulting in reduced patient benefit. Future work should focus on identifying factors that promote intervention sustainability in these settings. (Table Presented).

Clinical Features in Children and Adolescents Aged < 18 Years with Severe Covid in a Mexican Pediatric Critical Care Unit

BACKGROUND AND AIM: Overall mortality in children with severe COVID is less tan 1%. In Mexico, there are no reports regarding the epidemiology or clinical characteristics of severe covid. AIM: To describe clinical characteristics in children with severe outcomes and testing positive for SARS-CoV-2 in a pediatric critical care unit. METHOD(S): This retrospective cohort study enrolled participants between April 2020 and April 2021 in a pediatric terciary unit. Participants were youths aged younger than 18 years who were tested positive for SARS-CoV-2 infection and required hospitalization for severe COVID19. Main Outcomes and Measures: Severe outcomes, defined as intensive interventions during hospitalization (eg, inotropic support, positive pressure ventilation) or death. RESULT(S): Sixteen patients met the criteria for severe COVID according to the WHO definition4, 10 patients were men (62.5%) and 6 women (37.5%), with median age of 7.16 (0.2- 15, SD 4.95), 2 children have under 1 year (12.5%), 4 children aged 1-4 (25%), 7 children aged 5-11 (43.7%) and 3 aged 12-17 (18.7). (Table 1). A higher percentage of patients hospitalized for COVID-19 in our unit had an underlying condition (75%) compared with those without an underlying condition (25%) CONCLUSION(S): In our study, we found a high mortality in patients with severe COVID compared to that reported worldwide. In most of the countries across the world the mortality is less than 2%, but we found a 56% mortality. (Figure Presented).

Obtaining geographical competences through online cartography of familiar and unfamiliar urban heritage: lessons from student workshops

In times of the COVID-19 pandemic, teachers on all levels have had to adapt to an online or hybrid teaching environment. People in geography, a discipline that traditionally values field trips to connect theory to practice, have had to find online alternatives for educational activities that normally would have taken place in the field. This has led to several innovative practices, which, however, have only to a limited degree been purposively tested for efficacy because of the ad-hoc, enforced nature of the required changes. This project deals with this issue by studying, through student workshops dealing with the creation of online didactic walking routes in two cities, how students can obtain specific geographical competences such as interpreting different historical layers that collectively shape the current urban fabric through online cartography. We found that students reported clear improvements in geographical reasoning skills, regarding both GIS and heritage interpretation. There were no clear patterns regarding the role of familiarity with the studied city for the quality of the produced story maps. On final reflection, we argue that online cartographic exercises are a valuable addition to the geographers' educational toolkit to bounce forward to a more resilient, reflective educational practice after the pandemic.

A Nation-Wide Emergency Department Quality Initiative to Improve Care of Patients With Opioid Use Disorder

Background: To enhance dissemination of resources promoting evidence-based care of emergency department (ED) patients with opioid use disorder (OUD) and assess practices related to OUD care in EDs with a range of characteristics and resources, we developed the ACEP Emergency Medicine Quality Network (E-QUAL) Opioid Initiative. This national ED-focused practice-based learning network seeks to increase provision of naloxone and medication for the treatment of OUD (MOUD) by supporting local quality improvement (QI) through a curated toolkit with webinars and resources, a QI chart review to assess and benchmark ED care, and the dissemination of best practices. Method(s): In March of 2021, participating EDs were requested to complete a structured chart review of 30 randomly selected ED visits between September 2020 - February 2021 (baseline) with ICD-10 codes for opioid overdose or OUD, and to report on the following measures: substance use evaluation in the ED, naloxone offer/provision, MOUD administration (methadone or buprenorphine) in the ED, buprenorphine prescription at discharge, documented overdose prevention or harm reduction provision, and referral to OUD treatment. In November 2021, EDs were requested to review and submit metrics from an additional 30 charts for visits between July 2021- October 2021 (follow-up). Descriptive statistics and student's t tests were used to evaluate differences. Result(s): Among the 385 EDs participating in the 2021 E-QUAL Opioid Initiative learning collaborative, the median annual ED visit volume for adults was 14,552, with 138 (36%) classified as rural and 43 (11%) as critical access. Chart review data were submitted for 4,877 ED visits during the baseline period and 5,629 visits during follow-up. Between the baseline and follow-up periods, documented substance use evaluation in the ED increased from 89% to 93% (p<0.001) and OUD referral rate increased from 63% to 84% (p<0.001). Overall, the discussion or provision of naloxone (34% to 27%;p<0.001) and the documentation of overdose prevention and harm reduction counseling (67% to 60%;p<0.001) decreased across the two time points, although among the subset of patients with opioid overdose, naloxone discussion/provision increased (36% to 43%;p<0.001). Provision of buprenorphine and methadone in the ED (1% to 4%;p<0.001) and provision of an outpatient prescription of buprenorphine (2% to 3%;p<0.05) increased as well. Conclusion(s): EDs participating in a national practice-based learning network demonstrated improvement in several measures of ED OUD care. This study represents the first feasibility assessment of collection of measures from a nationwide sample including rural and community EDs for this purpose. Although improvements are modest, improved rates of OUD evaluation, treatment referral and MOUD treatment provision after participation in an online learning collaborative amidst the COVID-19 pandemic demonstrate the importance and potential for ongoing education and quality improvement. Yes, authors have interests to disclose Disclosure: Foundation for Opioid Response (FORE) Foundation Grant Support Foundation for Opioid Response (FORE) Foundation Copyright © 2022

Evaluating the Adaptation of a Secondary Teacher Training Programme: A Case in the Time of Pandemic

This paper has been prompted by the detection of some needs in secondary-school teacher training, especially as a result of the COVID-19 pandemic. In response, several training accessions are made from the initial teacher training programme. First, measures are included designed to facilitate the acquisition of digital competence, especially in teaching in online environments. Communication skills are also developed. The perception of trainee teachers is obtained after they start their period of teaching practice. Both of these actions are perceived as very positive, useful, and enriching for pupils. Teachers' confidence and experience were improved when they started their teaching practice. It is suggested that both of these subjects become mandatory before teaching is begun. Improvements include new learning environments and the strengthening of practical training. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Are drug-drug interactions clinically relevant? Use of edoxaban concomitant to ritonavir in COVID-19 hospitalized patients with atrial fibrillation

Background: During the first wave of the SARS-CoV- 2 pandemic, management of anticoagulation therapy in hospitalized patients with atrial fibrillation (AF) was simplified to low-molecular- weight heparin (LMWH), mainly due to the risk of drug-drug interactions. However, not all potential drug-drug interactions are clinically relevant. The metabolism of edoxaban by CYP3A4 is less than 4%, the risk of drug-drug interactions with edoxaban is low. There are few data on the interaction between edoxaban and ritonavir. Aim(s): To determine whether the effectiveness and safety of edoxaban or LMWH differed between patients with AF who had been hospitalized for COVID-19 infection and received empirical treatment with ritonavir. In addition, we analyzed length of stay, the proportion of patients requiring admission to the intensive care unit, and mortality. Method(s): Observational, retrospective, and multicenter study that consecutively included hospitalized patients with non-valvular AF who received anticoagulant treatment with LMWH or edoxaban concomitantly with empirical therapy for COVID-19 infection. Result(s): From March 5th to April 27th, 2020, 464 patients were included (80.3+/-7.7 years, 50.0% men, CHA2DS2-VASc 4.1 +/- 1.4;HAS-BLED 2.6 +/- 1.0). Regarding COVID-19 therapy during hospitalization, patients were taking azithromycin (98.7%), hydroxychloroquine (89.7%), and ritonavir/lopinavir (81.5%). The mean length of hospital stay was 14.6 +/- 7.2 days and mean total follow-up (from admission to the last visit) was 31.6 +/- 13.4 days. Furthermore, 12.9% of patients required admission to the intensive care unit, 18.5% of patients died, and 9.9% had a bleeding complication (34.8% major bleeding). Except for length of hospital stay, which was longer in patients taking LMWH (16.0 +/- 7.7 vs. 13.3 +/- 6.5 days;p = 0.005), data for the remaining outcomes were similar in patients treated with edoxaban and those treated with LMWH. Conclusion(s): No significant differences were found between patients treated with edoxaban and patients treated with LMWH in terms of the percentage admitted to the intensive care unit, mortality rates, arterial and venous thromboembolic complications, and bleeds. (Figure Presented).